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KMID : 0043319940170040249
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Archives of Pharmacal Research
1994 Volume.17 No. 4 p.249 ~ p.255
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A Novel Synthetic Route to 11-Deoxyanthracycline AB Synthons
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Kim Hee-Doo
Park Sang-Ae
Jew Sang-Sup
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Abstract
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An efficient synthetic method for 11-deoxyanthracycline AB synthons is described. A verstile key intemediate vinyl bromide 3 was prepared from 5- methodxy-1-tetralone in three steps, and then was converted to the allylic alcohols 4 and 8 which, in tum, fumished highly fuctionalized AB synthons 7 and 12, respectively, via sequential epoxidation-reduction-protection processes.
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KEYWORD
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11-Deoxyanthracycline, AB synthon, Vinyl bromide, Allylic alcohol, Epoxidation, 5-Methoxy-1-teralone
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